Eric Moss, PhD
Associate Professor
Molecular Biology
Office Address:
Science Center, Room B302
Two Medical Center Drive
Stratford
NJ
- 08084
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Contact:
Tel: 856-566-2896
Fax: 856-566-6291
mosseg@umdnj.edu
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Education
Columbia University,
NY
PhD
(Microbiology)
, 1990
University of Rochester,
NY
BS
(Microbiology)
, 1984
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Publications
Anna Polesskaya, Sylvain Cuvellier, Irina Naguibneva, Arnad Duquet, Eric G. Moss and Annick Harel-Bellan Lin-28 participates in skeletal myogenesis by increasing translation efficiency.
Genes Dev.. Vol. 21: 1125-38
(2007
)
.
Eric G. Moss Heterochronic Genes and the Nature of Developmental Time.
Curr. Biol. Vol. 17(11):: R425-434
(2007
)
.
Balzer, R., Moss, E.G. Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies, and stress granules.
RNA Biol. Vol. 4(20) :
(2007
)
.
Pepper ASR, McCane JE, Kemper K, Moss EG et al The C-elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin.
Development. Vol. May 2004;131(9): 2049-2059
(2004
)
.
Sempere LF, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E, Ambros V Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation.
Genome Biology. Vol. 2004;5(3):
(2004
)
.
Moss EG, Taylor JM Small-interfering RNAs in the radar of the interferon system.
Nature Cell Biology. Vol. Sep 2003;5(9): 771-772
(2003
)
.
Yang DH, Moss EG Temporally regulated expression of Lin-28 in diverse tissues.
Gene Expression Patterns. Vol. Dec 2003;3(6): 719-726
(2003
)
.
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Grants and Contracts
Title: Mechanisms in Developmental Timing
Sponsor: National Science Foundation
Effective Date(s): 2007 - 2009
Role: P.I.
Title: Phenotype of Lin28 mutant mice
Sponsor: UMDNJ Foundation
Effective Date(s): 2006 - 2007
Role: P.I.
Title: Mechanisms of Developmental Timing in C. elegans
Sponsor: National Science Foundation
Effective Date(s): 2002 - 2006
Role: P.I.
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Research Areas
We are investigating how development is controlled in the fourth dimension.: Animals posses explicit genetic regulatory mechanisms that control the timing and synchrony of developmental events. Interestingly, the molecules involved are unlike other developmental patterning regulators and often involve post-transcriptional gene regulation. Most prominent among these unusual regulators are the microRNAs which were discovered in the developmental timing pathway of the nematode C. elegans. We are combining biochemistry, molecular biology and genetics to dissect and explore the developmental timing mechanism.
We discovered that Lin-28, an RNA-binding protein and a key developmental timing regulator of C. elegans, is conserved from worms to humans. It appears to be a timing regulator in many developmental events in the mouse and to be regulated by microRNAs through its 3' untranslated region. We are using the power of mouse molecular and developmental biology to extend our understanding of timing from worms to mice and humans.
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