Michael Henry, PhD
Assistant Professor
Molecular Biology
Office Address:
Science Center, Room 322
Two Medical Center Drive
Stratford
NJ
- 08084
|
Contact:
Tel: 856-566-6970
Fax: 856-566-6291
henrymf@umdnj.edu
|
Education
University of IL at Urbana-Champaign,
IL
PhD
(Microbiology)
, 1992
University of IL at Urbana-Champaign ,
IL
MS
(Microbiology)
, 1988
Southern IL University-Carbondale,
IL
BA
(Microbiology)
, 1986
Top of page
Honors and Awards
1993-1996, American Cancer Society Postdoctoral Fellowship
Top of page
Publications
Balzer, R.J. and Henry, M.F Snu56p is required for Mer1p-activated meiotic splicing.
Mol Cell Biol. Vol. 28: 2497-508
(2008
)
.
Xu C, Henry MF Nuclear export of hnRNP Hrp1p and nuclear export of hnRNP Npl3p are linked and influenced by the methylation state of Npl3p.
Mol Cell Biol. Vol. Dec 2004;24(24): 10742-10756
(2004
)
.
Xu C, Henry PA, Setya A, Henry MF In vivo analysis of nucleolar proteins modified by the yeast arginine methyltransferase Hmt1/Rmt1p.
Rna. Vol. Jun 2003;9(6): 746-759
(2003
)
.
Henry MF, Mandel D, Routson V, Henry PA The yeast hnRNP-like protein Hrp1/Nab4 accumulates in the cytoplasm after hyperosmotic stress: a novel Fps1-dependent response.
Mol Biol Cell. Vol. Sep 2003;14(9): 3929-3941
(2003
)
.
Gratzer S, Beilharz T, Beddoe T, Henry MF, Lithgow T The mitochondrial protein targeting suppressor (mts1) mutation maps to the mRNA-binding domain of Npl3p and affects translation on cytoplasmic polysomes.
Molecular Microbiology. Vol. Mar 2000;35(6): 1277-1285
(2000
)
.
Gonzalez CI, Ruiz-Echevarria MJ, Vasudevan S, Henry MF, Peltz SW The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay.
Molecular Cell. Vol. Mar 2000;5(3): 489-499
(2000
)
.
Klein S, Carroll JA, Chen Y, Henry MF, et al Biochemical analysis of the arginine methylation of high molecular weight fibroblast growth factor-2.
Journal of Biological Chemistry. Vol. Feb 4 2000;275(5): 3150-3157
(2000
)
.
Top of page
Grants and Contracts
Title: Use of a genetically amenable model organism to identify potential autism predisposition genes
Sponsor: UMDNJ Foundation
Effective Date(s): 2009 - 1010
Role: PI
Title: The yeast Saccharomyces cerevisiae as a model organism for autism
Sponsor: UMDNJ Foundation
Effective Date(s): 2007 - 2008
Role: P.I.
Title: Hypoxia induced nuclear-mitochondrial protein transport
Sponsor: UMDNJ Foundation
Effective Date(s): 2006 - 2007
Role: P.I.
Top of page
Research Areas
Posttranslational Modification: The goal of my research is to examine the cellular mechanism by which mRNA precursors are processed in the nucleus, using the budding yeast Saccharomyces cerevisiae as a model system. I plan to focus on the role of posttranslational modification in this process. Although significant progress has been made in identifying the proteins required for RNA maturation in both yeast and mammals, the set is not yet complete, and the mechanisms by which they act remain poorly understood. A better understanding of this process not only has implications for oncology but also can provide insights into viral mechanisms for RNA maturation during cell infection.
Top of page
|
